CBD for Restless Legs Syndrome: Unabis Overview – Unabis
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CBD for Restless Legs Syndrome: Unabis Overview

By Jerry HuntNovember 10, 2021February 10th, 2022CBD Blog, CBD FOR ANXIETY, CBD FOR PAIN RELIEF

Sometimes, it’s not the B-rated horror movie you’ve watched that keeps you up at night. Sometimes, it’s the debilitating pain from the nighttime leg twitching, or more aptly called the restless legs syndrome (RLS). Now, fret not—there’s a solution for this worry of yours. Using CBD for restless legs syndrome, you can still doze off your way to dreamland. 

Facts and Figures You Need to Know About Restless Legs Syndrome

Before we get into it and lobby behind CBD for restless legs syndrome, it pays to know first what we are dealing with, and to some extent, who else is dealing with it. Believe it or not, some might not even know they need CBD for restless legs syndrome because their RLS has been left undiagnosed even up to this day! Here are some numbers to give you an overview, and why we take CBD for RLS into consideration:

  • 7-10% of Americans have RLS. And this number only encompasses the diagnosed ones. Whenever you feel something different in your body, it’s your body telling you something is wrong with it. Seek professional medical advice immediately.
  • Over 80% of RLS patients experience periodic limb movement of sleep (PLMS). PLMS involves repetitive limb movements (most of the lower extremities) that occur mostly during the light non-REM part of sleep. Unlike RLS, which can be diagnosed clinically, PLMS needs polysomnography to be detected. We should also note that not all PLMS patients are RLS patients.
  • RLS is more prevalent with women, as compared to men; and, it is prevalent with people with no comorbidities, in general. According to a study, RLS was widely spotted among a population with fewer comorbidities, with women filling the chunk. It is also to be noted that sleep-related complaints were apparent—another reason CBD for restless legs syndrome has gained traction. 
  • 1 in 5 pregnant women experiences RLS in their last trimester. RLS is the most common movement disorder during pregnancy. Being affected with RLS during the third trimester is very alarming since rest is a must during this important moment in a woman’s life. In a study, it was stated that there is a relation between sleep disorders and pregnancy complications. Note: Despite what the data says, if you’re pregnant, avoid self-medication—including taking CBD for restless legs syndrome. Health professionals, with clinical risk management mandates under their belt, need to keep watch on CBD intake.
  • The onset of symptoms appears before 40. It may begin at any age, even as early as childhood. However, researches show that severe symptoms can likely appear as you get old if not taken care of. Note: You have to be 18 or older and even 21 or older to take CBD oil for restless legs syndrome. Mind that CBD laws vary from state to state.

Why Choose CBD for restless legs syndrome (RLS)?

There has been a lot of buzz going around about the potential of CBD for RLS syndrome. It’s truly amazing how much hype CBD got because of its wonders for RLS and other illnesses. However, everything comes at a cost. We shouldn’t deny that on the other side of the coin, there is still some stigma about it—and also tight regulations—because of its close association with marijuana. Therefore, here are some facts that can help you decide if CBD for restless legs syndrome is the right choice for you.

CBD differs from THC; it’s celebrated for the right reasons 

CBD and THC are both cannabinoids found in the cannabis plant. However, CBD is one of a kind, as it has notable anecdotal benefits and it doesn’t have THC’s ‘getting high’ trigger. Small amounts of THC (that don’t reach FDA’s limits) can be a great addition to CBD for RLS.

CBD for RLS is legal, to some extent. 

Farm Bill was signed into law in 2018, which then legalized CBD derived from the hemp plant. While hemp-derived CBD is federally legal, marijuana-derived CBD products’ legality is a bit complicated, depending on the state you’re in. Every state’s law regarding CBD consumption (and even selling) will differ. Better check first with your state, before we find a good CBD for restless legs syndrome for you.

More and more people are using CBD oil for RLS and will continue to do so. Because of the absence of psychoactive effects, people are adopting the use of CBD-derived products, such as CBD oil drops, CBD gummies, CBD softgels and CBD cream for restless legs syndrome. In fact, according to Brightfield Group, we expect CBD to reach $16 billion by 2025.

Only a few medical CBD-derived products are FDA-approved yet. Various CBD products are medically used to treat ailments. For example, there’s Epidolex, for seizure treatment, and then Marinol, Syndros, and Cesamet, for treatment of vomiting and nausea caused by chemotherapy. There is still a lot of in-depth research about CBD going on; scientific pieces of evidence for CBD for RLS and other more ailments in the future are what every industry is hoping for. Note: all CBD for RLS sold in the market must undergo and pass FDA tests and regulations to ensure the public health is safe from any risk. So, as long as FDA gives a product that has CBD oil for RLS a go-signal, you’re safe!

CBD for RLS comes in different forms because of different reasons

It’s easy to enjoy CBD’s therapeutic effects since CBD for RLS offers product variety according to potency. According to a study, the best way to enjoy the benefits of CBD is to opt for a formula with terpenes coupled with cannabinoids, and not just one cannabinoid (i.e., purest form, CBD Isolate).

CBD for RLS: There is science plus significant anecdotal evidence to it

How ironic—and even maddening—that discomfort kicks in just when you’re ready to end a tiring day and to finally dive into that bed to slumber. Here’s how CBD helps alleviate symptoms from RLS!

CBD for RLS: Interacting with Dopamine Receptors

Facts: According to a study, if there’s iron insufficiency in the brain, abnormalities in dopamine levels occur, and thus, result in restless legs syndrome. An apparent decrease in dopamine receptors and an increase in proteins producing dopamine were also noticed. As for treatment, ensuring iron sufficiency, with either dietary or intravenous methods, can relieve RLS symptoms. 

Can CBD for RLS support achieving optimal levels of iron in your brain? Iron deficiency symptoms include weakness, fatigue, and exhaustion, and this will affect your diet. It might be a long way, but CBD for RLS has appetite-increasing side effects that can help you get back on track.

Can CBD for RLS help in correcting dopaminergic abnormalities? Some findings show that chronic cannabis use is associated with a decrease in dopamine synthesis capacity and thus debunks the myths around its psychotic effects. Taking CBD for RLS affects dopaminergic modulation.

CBD for RLS: Easing You to A Good Night Sleep

Facts: RLS can’t be diagnosed with a sleep study. However, RLS’ primary symptom—the constant urge to move your leg)—will keep you up at night. As guided by a sleep specialist, taking OTC sleeping pills will make RLS even worse.

Can CBD give you that most sought rest you need? CBD for RLS and as a sleep aid is well-backed. The potential of cannabis use for RLS was first reported in a case study, where all patients testified they achieved sleep improvement and symptoms alleviation from RLS.

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CBD for RLS: Reducing Inflammations

Fact: According to a study, 95% of the 38 conditions highly linked to RLS have shown a strong relation with inflammation as suggested by the noticeable increase in the blood levels of the C-reactive protein (CRP).

Can CBD help in reducing inflammations? Researchers say there is evidence about CBD’s potential for reducing inflammation in animals. In addition, anecdotal pieces of evidence point that CBD for RLS may also be used for inflammation in humans.

CBD for RLS: Managing Muscle Pains and Involuntary Movement

Fact: PLMD, or nocturnal myoclonus, is closely associated with RLS (as mentioned before), and causes leg muscle jerking every 20 to 40 seconds. In addition, it was observed with hemodialysis patients with restless legs syndrome that there is increasing evidence of muscle atrophy and can be attributed also to patients’ reported sleep deprivation.

Can CBD help alleviate the excruciating pain? Establishing CBD’s full effect on chronic pain is still what we patiently wait for. However, with researches on patients who experience chronic pain, it has been reported that CBD consistently improves a patient’s quality of life.

Can CBD help prevent involuntary movements? In a study, it was mentioned that CBD may prevent movement disorders like Parkinson’s disease and dyskinesia. Just like RLS, though not entirely similar, those movement disorders have neurologic relations.

What Type of CBD for RLS Should I buy?

It’s amazing how CBD has been beneficial to people’s ailments when you hear their stories—so what more with the potential of CBD for RLS? The researches above hopefully incite some discussion within you. ‘Should I give products with CBD for RLS a try?’ Well, if you’re already convinced enough that taking CBD for restless legs syndrome may work, it’s now time to research what CBD product should you buy. CBD for RLS comes in various forms and sizes, and you’ll be surprised by how easy it is to find the perfect one for your needs. 

CBD Topicals

Includes: CBD lotions, CBD salves, and CBD cream for restless legs syndrome.

What’s the best topical with CBD for restless legs syndrome out there? From a topical medication and cosmetic viewpoint, the cream is 50% oil and 50% water, a lotion is a ‘thinner cream’, an ointment on the is 80% oil in composition, a gel is oil-free (just a combination of cellulose, water, and alcohol). And your choice will depend on your skin condition and your needs. Do you want some soothing effect from another ingredient aside from CBD’s therapeutic benefits? Does it get cold easily in your area? Then, maybe it’s best to go for a cream that has CBD for RLS effects and azulene from chamomile for soothing effects, for example. Again, it depends on your preferences.

Looking for an effective CBD topical to fight restless legs syndrome? Take advantage of our natural CBD Balm!

What do I need to know before applying or slathering CBD for RLS?

 We’ve presented various studies about CBD oil and RLS. Go read further to find out crucial aspects you should know before applying CBD for restless legs syndrome. 


For external application, you can apply them directly to the affected area—whether it be pain, muscle spasms, and so on—as long as there are no open wounds. Now, what you should be mindful of when looking for the best CBD cream for restless legs syndrome is its source. Do you want the CBD for RLS to be THC-free? Will you have allergic reactions to its other composition? (Well, every FDA-approved product claiming to have CBD for RLS should contain this pertinent information.

CBD Edibles 

Includes: CBD liquids (teas, juices, etc.), CBD capsules, CBD oil, and CBD gummies 

What’s the best edible with CBD for restless legs syndrome out there? CBD for RLS in capsule or oil forms is the best since they offer accurate dosing, unlike CBD liquids. CBD Oils would be a better choice for those who don’t like capsules. You can choose from: full-spectrum CBD oil, broad-spectrum CBD oil, and CBD isolate. CBD oils have been the #1 choice since you can choose sublingual CBD administration, easily incorporate it into your recipes or mix it with your afternoon cup of tea, for example. 

As for bioavailability, CBD oil is the best consumption of CBD for RLS. Choose the CBD oil to your taste in the Unabis CBD store!

What do I need to know when ingesting CBD for RLS

According to research, absorption of CBD can take time before it goes into the bloodstream, and then finally takes effect. FDA is very wary about new CBD edibles most since they can cause harm through food poisoning. Dosage of CBD for restless legs syndrome—just like with any ailments—should be consulted with your doctor at all times.

Can I mix and match CBD products to get the most out of CBD for RLS?

As they say, too much of everything can be bad—CBD for RLS is no exception. There is only a proper amount a human can safely digest, and it’s around 1500 mg per day. This should not be a problem for a consumer if he reads everything on the labels of CBD products and is mindful enough. However, if you’re taking other medications and supplements, better talk with a healthcare professional about consuming only CBD for RLS.

Worry less; CBD Oil for Restless Legs Syndrome has a lot of potential 

Symptoms from RLS can be indirectly bothersome to our career, our lifestyle, and even our relationships. No more time for early morning runs, no more cozy breakfasts with your family, and no more energetic you gracing the workplace. The worst part is your partner who you share your bed with might be having some challenges too! CBD for restless legs syndrome, with proper intake as advised by a professional, might remove all those worries.


I am a cannabis and CBD advocate, researcher, and author with over 7 years of experience in consulting CBD producers and sellers on various industry matters. I graduated from OSU, majoring in biology. I live in Seattle with my dog Han and my cat Leia.


Can I take CBD oil in the morning for restless legs?

The time for taking CBD oil for restless legs depends on your preferences and lifestyle. Thus, if you’re comfortable with taking CBD oil for restless legs in the morning, you can surely do it.

What is the dose of CBD to treat RLS?

The appropriate dosage of CBD for restless legs syndrome depends on a lot of factors like your weight, tolerance towards CBD, severity of the RLS, and others. When choosing the dosage for yourself, you can either consult your healthcare provider, or start small and correct your dosage if needed.

Can CBD help RLS?

There’s anecdotal evidence showing that CBD can indeed help treat restless legs syndrome.

What is the best CBD oil and strength for RLS?

When choosing CBD oil to fight restless legs syndrome, try selecting CBD brands that use full-spectrum CBD oil, provide access to their products’ laboratory testing results, and have positive feedback from customers.

As for the strength of the CBD oil, it depends on many factors and it’s better to consult this matter with a healthcare professional or start small.

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